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Cognitive development of the children of mothers with epilepsy

The cognitive development of the children born to mothers with epilepsy may be affected by intrauterine hypoxia caused by maternal seizures, the teratogenicity of antiepileptic drugs (AEDs), social and family factors associated with chronic maternal illness, and possibly genetic factors. German and Swiss investigators have reported a study in Berlin (Karl Titze and colleagues. Developmental Medicine and Child Neurology 2008;50:117–22) that provides data about the first three of these factors.

This report is a follow-up from a study begun in Berlin in 1977 and reported in 1994, and includes 116 of the 344 children in the original study. At follow up in 1998 there were 63 females and 53 males aged 10–20 years (mean 14 years); 67 had mothers with epilepsy (study group) and 49 had mothers without epilepsy (controls). Among the study group, 31 had been exposed in utero to AED monotherapy, 23 to polytherapy, and 13 . . . [Full text of this article]